Established as Burleson in the early 1850s, the town's name was changed to Lampasas with the creation of Lampasas County when it was made the county seat. Sulphur springs, popular among Indians long before white settlers arrived, still flow hardly half a mile from the native stone courthouse, which is listed on the National Register of Historic Places. Another historic structure is the Keystone Hotel, an early Texas landmark-stagecoach stop. Sportsmen find prime hunting for white-tailed deer, wild turkey, quail, mourning dove, and excellent fishing in local creeks and nearby Lampasas and Colorado Rivers.
Lampasas is a Texas Main Street Project. Downtown buildings feature local limestone construction in which several have been restored and others are planned. Most of the buildings were originally built in the 1880s. A historical driving tour is available at the Chamber of Commerce office.
Lampasas lies on U.S. 190, a segment of the Ports to Plains Highway connecting the state's heartland to coastal ports.