The original heart of Sanderson, the Sanderson Depot is located on historic Downie Street. The Great American Station Foundation recently designated the Sanderson Depot as one of the ten most endangered stations in America.
Terrell County received a Transportation Enhancement Grant in 2001 for renovation of the Depot. Plans are to showcase the importance of railroading and ranching, major parts of the town's historical character, in a Transportation and Heritage Museum to be located in the renovated Sanderson Depot. Estimated completion date: 2005