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Clarksville, Missouri

The mighty Mississippi was the lifeblood of many Missouri towns for over a century. The Missouri Great River Road is a route with stories to tell and a history to preserve. Civil War History and the movement west are just two of the great American stories that the byway has to tell.

Interpretive sites are being established along this 30 mile section of the Great River Road in Missouri beginning at the southern boundary of Clarksville. Numbered signs are positioned for the visitor to make stops along the way.

Attractions and Upcoming Events

Clarksville Museum

The Clarksville Museum, operated by a volunteer board, covers the history of the town from its founding in 1817

Clarksville, MO Museums

River Heritage and Visitor Center

The Clarksville Tourist Information Center serves to showcase attractions and sights for those traveling the Great River Road. It overlooks the U. S. Lock and Dam #24, providing a close vantage point to view all river boat and barge traffic and a 'front row seat'

Clarksville, MO Visitors Centers

The Great River Road Scenic Byway

The mighty Mississippi was the lifeblood of many Missouri towns for over a century. The Missouri Great River Road is a route with stories to tell and a history to preserve. Civil War History and the movement west are just two of the great American stories that the byway has to tell.

Clarksville, MO Scenic Byways

Historic Downtown District

The commercial district in Clarksville is listed on the National Register of Historic Places

Clarksville, MO Historic Districts


Things to do near Clarksville, MO

Twainland Express Sightseeing Tours

Enjoy a 1-hour narrated tour on old-fashioned locomotive-styled tour train. Comfortable cushioned seating. Group and family r...

Molly Brown Birthplace & Museum

Three rooms of period antiques (1860s-1880s) depicting an Irish immigrant's cottage and two rooms of photos and displays of M...

Optical Science Center & Museum

Light show, optical science demonstrations, hands-on learning fun, hundreds of glasses on display, indoor theatre, fun for th...