The museum features a diorama complete with prehistoric fossils uncovered locally. This diorama shows life as it progressed over the millenia on the High Plains, and includes furniture and period exhibits of frontier life. All of the exhibits are of Cheyenne County history.
The St. Francis City Campground and Rest Area is located just adjacent and behind the Cheyenne County Museum and welcomes travelers at no charge.
There are electrical hookups, drinking water, showers and restrooms, sanitary dump station, and handicapped accessible.